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Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers
Dorota Kida1, Tomasz Konopka2, Kamil Jurczyszyn3
1Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
Biomedicines
|May 27, 2023
Summary
This study explores polymer matrices for dental drug delivery, detailing fabrication methods like solvent-casting, lyophilization, electrospinning, and 3D printing. It also covers essential testing for optimizing drug carriers for the oral environment.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biomedical Engineering
Background:
- Dental drug delivery systems require advanced polymer matrices for effective therapeutic outcomes.
- Technological aspects, including composition and manufacturing, critically influence carrier performance.
- Assessing carrier behavior at the application site is crucial for clinical success.
Purpose of the Study:
- To review and characterize methods for fabricating dental drug carriers.
- To describe essential testing methodologies for evaluating dental drug carrier properties.
- To provide insights for optimizing dental drug formulations for prolonged oral retention.
Main Methods:
- Solvent-casting method (SCM)
- Lyophilization method (LM)
- Electrospinning (ES)
- 3D printing (3DP)
- Physical, chemical, pharmaceutical, biological, and in vivo evaluations
Main Results:
- Fabrication methods (SCM, LM, ES, 3DP) have distinct advantages and limitations.
- Comprehensive in vitro evaluation aids in optimizing formulation parameters.
- Understanding carrier properties is key to predicting in vivo performance.
Conclusions:
- Optimized polymer matrices are essential for effective dental drug delivery.
- Rigorous testing protocols are necessary to ensure carrier efficacy and safety.
- This review guides the selection of optimal dental drug carrier formulations.
