Related Experiment Video
Updated: Jul 29, 2025

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
Published on: September 11, 2017
Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular
Sayaka Anazawa1, Koya Yamashiro2,3, Taiki Makibuchi1,2
1Field of Health and Sports, Graduate School of Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-Ku, Niigata 950-3198, Japan.
Background And Objectives:
We examined sex differences in the excitatory and inhibitory functions of the primary somatosensory cortex (S1) between males and females during the early follicular phase, when estradiol hormones are unaffected.
Methods:
Fifty participants (25 males and 25 females) underwent measurement of somatosensory evoked potentials (SEPs) and paired-pulse inhibition (PPI) in the S1; SEPs and PPI were elicited by constant current square-wave pulses (0.2 ms duration) delivered to the right median nerve by electrical stimulation. Paired-pulse stimulation occurred at 30- and 100-ms interstimulus intervals. Participants were randomly presented with 1500 (500 stimuli each) single- and paired-pulse stimuli at 2 Hz.
Results:
The N20 amplitude was significantly larger in female subjects than in male subjects, and the PPI-30 ms was significantly potentiated in female subjects compared to that in male subjects.
Conclusions:
The excitatory and inhibitory functions in S1 differ between male and female subjects, at least during the early follicular phase.
More Related Videos
10:19Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
Published on: March 31, 2016
06:18Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
Published on: November 21, 2023
Related Concept Videos
Somatosensation
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Somatosensory, Motor, and Association Cortex