Related Experiment Video

Updated: Jul 29, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

27.5K

Regulation of the Cell Cycle by ncRNAs Affects the Efficiency of CDK4/6 Inhibition

Qingyi Hu1, Tao Huang1

  • 1Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

International Journal of Molecular Sciences
|May 27, 2023
PubMed

Insights

Selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are vital cancer therapies. Cell cycle-regulating non-coding RNAs (ncRNAs) influence treatment outcomes and may serve as biomarkers for CDK4/6 inhibition efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cyclin-dependent kinases (CDKs) are crucial regulators of the cell cycle, and their dysregulation drives cancer proliferation.
  • Selective CDK4/6 inhibitors represent a significant advancement in cancer therapy, forming a cornerstone of treatment for various malignancies.
  • Non-coding RNAs (ncRNAs) play a role in cell cycle regulation and are frequently dysregulated in cancer, but their precise impact on CDK4/6 inhibition is under investigation.

Purpose of the Study:

  • To explore the role of cell cycle-associated ncRNAs in the context of CDK4/6 inhibition therapy.
  • To investigate how ncRNAs may modulate the efficacy of CDK4/6 inhibitors in cancer treatment.
  • To identify potential roles for ncRNAs as predictive biomarkers or therapeutic targets for CDK4/6 inhibition.

Main Methods:

  • Literature review of preclinical studies investigating ncRNAs and cell cycle regulation.
  • Analysis of existing data on ncRNA expression in cancer patients undergoing CDK4/6 inhibition.
  • In silico and in vitro experiments to elucidate mechanisms of ncRNA-CDK4/6 inhibitor interaction (details not provided in abstract).

Main Results:

  • Preclinical evidence suggests that ncRNAs can either enhance or diminish the effectiveness of CDK4/6 inhibitors.
  • Specific ncRNAs interact with key cell cycle regulators, influencing cellular response to targeted therapy.
  • Abnormal expression patterns of certain ncRNAs correlate with treatment outcomes in preclinical models.

Conclusions:

  • Cell cycle-associated ncRNAs are implicated in modulating the response to CDK4/6 inhibition.
  • ncRNAs show promise as predictive biomarkers for patient stratification in CDK4/6 targeted therapies.
  • Targeting ncRNAs could represent a novel therapeutic strategy to improve outcomes for CDK4/6 inhibitor treatment.
Keywords:
CDKCDK4/6 inhibitioncell cyclechemotherapynon-coding RNA

More Related Videos

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.4K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.5K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.2K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.5K
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
3.1K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.2K