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Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes?
James Tebby1, Vasileios P Giannoudis1, Sophia M Wakefield1
1Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds LS2 9LU, UK.
Insights
Diabetes increases mortality risk in polytrauma patients, even with advances in trauma care. This study highlights diabetes as an independent risk factor for death following major trauma.
Area of Science:
- Trauma Surgery
- Diabetology
- Epidemiology
Background:
- Managing polytrauma patients is complex, especially those with comorbidities like diabetes.
- Diabetes mellitus can lead to unpredictable outcomes and increased mortality in trauma patients.
Purpose of the Study:
- To investigate the impact of major trauma centers in the UK on polytrauma patient outcomes.
- To analyze the specific outcomes of polytrauma patients with diabetes mellitus.
Main Methods:
- Utilized the Trauma Audit and Research Network (TARN) database.
- Included 32,345 polytrauma patients from England and Wales (2012-2019).
- Categorized patients into three groups: diabetes, other comorbidities, and no comorbidities.
Main Results:
- Despite overall reduced mortality, diabetic patients had higher mortality rates.
- Increasing Injury Severity Score (ISS) and age correlated with increased mortality.
- Diabetes was an independent predictor of mortality (OR 1.36, p < 0.0001), even after adjusting for age, ISS, and Glasgow Coma Score.
Conclusions:
- The prevalence of diabetes mellitus in polytrauma patients is increasing.
- Diabetes mellitus remains a significant independent risk factor for mortality in polytrauma patients.
- Improved trauma care has reduced mortality across groups, but diabetes continues to pose a higher risk.
Abstract:
The management of patients with multiple injuries remains challenging. Patients presenting with comorbidities, such as diabetes mellitus, may have additional unpredictable outcomes with increased mortality. Therefore, we aim to investigate the impact of major trauma centres in the UK on the outcomes of polytrauma patients with diabetes. The Trauma Audit and Research Network was used to identify polytrauma patients presenting to centres in England and Wales between 2012 and 2019. In total, 32,345 patients were thereby included and divided into three groups: 2271 with diabetes, 16,319 with comorbidities other than diabetes and 13,755 who had no comorbidities. Despite an overall increase in diabetic prevalence compared to previously published data, mortality was reduced in all groups, but diabetic patient mortality remained higher than in the other groups. Interestingly, increasing Injury Severity Score (ISS) and age were associated with increasing mortality, whereas the presence of diabetes, even when taking into consideration age, ISS and Glasgow Coma Score, led to an increase in the prediction of mortality with an odds ratio of 1.36 (p < 0.0001). The prevalence of diabetes mellitus in polytrauma patients has increased, and diabetes remains an independent risk factor for mortality following polytrauma.
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