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Management of the Sickle Cell Trait: An Opinion by Expert Panel Members

Valeria Maria Pinto1, Lucia De Franceschi2, Barbara Gianesin1,3

  • 1Centro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, E.O. Ospedali Galliera, 16128 Genova, Italy.

Journal of Clinical Medicine
|May 27, 2023
PubMed

Insights

Sickle Cell Trait (SCT) affects over 300 million globally and is linked to health risks beyond being a carrier. Increased awareness of SCT complications is vital for healthcare providers.

Area of Science:

  • Genetics and Hereditary Diseases
  • Public Health
  • Clinical Medicine

Background:

  • Sickle cell disease is a prevalent monogenetic disorder, impacting over 300 million people worldwide.
  • Sickle Cell Trait (SCT) is common, necessitating effective reproductive counseling.
  • SCT is increasingly recognized as a risk factor for various clinical complications.

Purpose of the Study:

  • To highlight the clinical significance of Sickle Cell Trait (SCT).
  • To inform healthcare providers about SCT-related health risks.
  • To emphasize the importance of prevention and management strategies for SCT complications.

Main Methods:

  • Expert panel review of current literature and clinical observations.
  • Synthesis of data on the prevalence and impact of SCT.
  • Identification of key clinical manifestations associated with SCT.

Main Results:

  • Sickle Cell Trait (SCT) is associated with significant health risks, including exertional injury, kidney disease, and surgical/pregnancy complications.
  • The high global prevalence of SCT underscores the need for informed reproductive and clinical management.
  • Existing knowledge gaps regarding SCT complications hinder optimal patient care.

Conclusions:

  • Healthcare providers require enhanced knowledge of SCT's clinical manifestations.
  • Proactive management and prevention strategies are essential for individuals with SCT.
  • Further education on SCT is crucial for improving patient outcomes and public health.

Keywords:
exertional rhabdomyolysishemoglobinopathieskidney diseasepainpregnancysickle cell traitspecialist advicespleen infarctionsurgerytransplantation

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