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Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
Published on: November 8, 2017
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Condition "Vasa Vasorum" in Patients with Thoracic Aortic Aneurysm
Petr V Chumachenko1,2, Alexandra G Ivanova1, Mariam Bagheri Ekta1
1Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia.
Journal of Clinical Medicine
|May 27, 2023
Summary
Inflammatory cells and vasa vasorum (small blood vessels) play a crucial role in thoracic aortic aneurysm development. Pathological changes in vasa vasorum, including T cell infiltration and blood clots, significantly impair aortic wall blood supply.
Area of Science:
- Cardiovascular Biology
- Immunology
- Vascular Pathology
Background:
- Vasa vasorum (VV) supply the outer third of the ascending thoracic aorta.
- The role of VV in aortic aneurysm pathogenesis is not fully understood.
- Inflammatory cell infiltration is a hallmark of aortic aneurysms.
Purpose of the Study:
- To investigate the relationship between inflammatory cells and vasa vasorum in thoracic aortic aneurysms.
- To assess the impact of vasa vasorum pathology on aortic wall blood supply in aneurysm patients.
Main Methods:
- Immunohistochemical analysis of thoracic aortic aneurysm biopsies (n=48).
- Antibodies used: T cells (CD3, CD4, CD8), macrophages (CD68), B cells (CD20), endothelium (CD31, CD34, vWF), smooth muscle cells (alpha actin).
- Comparison of vasa vasorum characteristics in samples with and without inflammatory infiltrates.
Main Results:
- Samples with inflammatory infiltrates had significantly less vasa vasorum in the tunica adventitia (p < 0.05).
- T cells adhered to vasa vasorum endothelium in 28/48 patients, more prevalent in those with inflammation (p < 0.0006).
- Vasa vasorum showed hypertrophy, sclerosis, lumen narrowing, T cell infiltration, and thrombosis in a significant number of patients, impairing aortic wall perfusion.
Conclusions:
- The state of vasa vasorum is critically important in the development of thoracic aortic aneurysms.
- Pathological changes in vasa vasorum, including inflammatory cell infiltration and thrombosis, significantly contribute to aortic aneurysm pathogenesis.
- Impaired blood supply via vasa vasorum is a key factor in aortic wall degeneration.
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