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Related Experiment Video

Updated: Jul 29, 2025

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
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Non-Invasive Brain Stimulation for the Modulation of Aggressive Behavior-A Systematic Review of Randomized

Antony Casula1, Bianca M Milazzo1, Gabriella Martino2

  • 1Dipartimento di Scienze Cognitive, Psicologiche, Pedagogiche e Degli Studi Culturali, Università di Messina, 98121 Messina, Italy.

Life (Basel, Switzerland)
|May 27, 2023
PubMed
Summary

Non-invasive brain stimulation (NIBS) shows promise in reducing aggression. Techniques like tDCS and rTMS, targeting the prefrontal cortex, offer potential therapeutic benefits for various populations.

Keywords:
aggressioncTBSnon-invasive brain stimulationrTMStDCS

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuromodulation

Background:

  • Aggressive behavior is a major public health concern with broad societal impacts.
  • Non-invasive brain stimulation (NIBS) offers a potential avenue for modulating aggression via prefrontal cortex stimulation.

Purpose of the Study:

  • To systematically review the efficacy of NIBS in altering aggressive behavior.
  • To analyze findings, limitations, stimulation techniques, and clinical implications of NIBS for aggression.

Main Methods:

  • A systematic literature review of PubMed was conducted.
  • Included 17 randomized sham-controlled studies on NIBS and aggression.
  • Excluded reviews, meta-analyses, and studies not focused on cognitive/emotional modulation.

Main Results:

  • tDCS, conventional rTMS, and cTBS show promising effects on aggression in healthy, forensic, and clinical samples.
  • The stimulation target is crucial for successful aggression modulation.
  • rTMS and cTBS demonstrated effects opposite to tDCS.

Conclusions:

  • NIBS techniques like tDCS and rTMS present a promising approach for managing aggression.
  • Target specificity is a critical determinant of treatment efficacy.
  • Further research is needed to address heterogeneity in protocols and confounding factors.