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Endometrial Cancer Staging: Is There Value in ADC?

Ana Sofia Linhares Moreira1, Vera Ribeiro2, Giacomo Aringhieri3

  • 1Radiology Department, Centro Hospitalar Universitário do Algarve, 8000-386 Faro, Portugal.

Journal of Personalized Medicine
|May 27, 2023
PubMed
Summary
This summary is machine-generated.

Apparent diffusion coefficient (ADC) measurements cannot predict endometrial cancer grade. However, MRI interpretation shows good agreement with histopathology for cancer staging.

Keywords:
apparent diffusion coefficientdiffusion-weighted imagingdynamic contrast-enhanced magnetic resonance imagingendometrial cancergradingmagnetic resonance imagingstaging

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Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Endometrial cancer diagnosis and staging are crucial for treatment planning.
  • Magnetic Resonance Imaging (MRI) is a key modality for evaluating endometrial cancer.
  • Apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is explored for its predictive potential.

Purpose of the Study:

  • To evaluate the efficacy of apparent diffusion coefficient (ADC) measurements in predicting the histological grade of endometrial cancer.
  • To assess the agreement between MRI and surgical staging in endometrial cancer.

Main Methods:

  • Retrospective analysis of 45 endometrial cancer patients diagnosed between 2018-2020.
  • Characterization by histology, tumor size, FIGO stage (MRI and surgical), and MRI parameters (DCE, DWI/ADC).
  • Statistical analysis to correlate ADC variables with histological grade and assess MRI-surgical stage agreement.

Main Results:

  • No statistically significant association was found between ADC variables and histological tumor grades.
  • Dynamic contrast-enhanced (DCE) MRI demonstrated higher sensitivity for myometrial invasion assessment compared to DWI/ADC.
  • Good agreement (kappa = 0.72) was observed between MRI and histopathology for FIGO staging.

Conclusions:

  • ADC values are not effective predictors of endometrial cancer histological grade.
  • MRI interpretation demonstrates reliable agreement with histopathology for endometrial cancer staging.