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Lung and Gut Microbiome in COPD.
Efstathios Karakasidis1, Ourania S Kotsiou1,2, Konstantinos I Gourgoulianis1
1Department of Respiratory Medicine, School of Health Science, University of Thessaly, Biopolis, 41110 Larissa, Greece.
Journal of Personalized Medicine
|May 27, 2023
Summary
The lung and gut microbiomes are linked in chronic obstructive pulmonary disease (COPD) development. Further research is needed to understand microbiome diversity
Area of Science:
- Pulmonary Medicine
- Microbiology
- Genetics
Background:
- Chronic obstructive pulmonary disease (COPD) is a major global health concern.
- Emerging research highlights the interconnectedness of lung and gut microbiomes in disease.
- Understanding these microbial communities is crucial for COPD pathogenesis.
Purpose of the Study:
- To review the role of lung and gut microbiomes in COPD pathophysiology.
- To examine the association between microbiome dysbiosis and COPD progression.
- To identify research gaps in microbiome-targeted COPD interventions.
Main Methods:
- Systematic literature search of PubMed database up to June 2022.
- Analysis of studies investigating lung and gut microbiome alterations in COPD patients.
- Inclusion of data from bronchoalveolar lavage, lung tissue, sputum, and fecal samples.
Main Results:
- Evidence supports a significant interaction between lung and gut microbiomes in COPD.
- Microbiome dysbiosis in both sites is associated with COPD pathogenesis and progression.
- Specific associations between microbial diversity and COPD exacerbations require further investigation.
Conclusions:
- The lung and gut microbiomes are integral to COPD development and progression.
- Further research is essential to elucidate precise mechanisms and therapeutic targets.
- Microbiome-focused interventions hold potential for preventing and managing COPD.
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