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Focal Segmental Glomerulosclerosis Followed by Acute Hepatitis A Infection: Case Report

Min-Woo An1, Jeong-Ju Yoo1, Jin Kuk Kim2

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon 14584, Republic of Korea.

Medicina (Kaunas, Lithuania)
|May 27, 2023
PubMed

Insights

Acute hepatitis A virus (HAV) infection, though rare, can cause nephrotic syndrome, specifically focal segmental glomerulosclerosis (FSGS). Prompt recognition and treatment are crucial for persistent symptoms like proteinuria.

Area of Science:

  • Nephrology
  • Hepatology
  • Virology

Background:

  • Chronic viral hepatitis (B, C) commonly causes nephropathies.
  • Acute hepatitis A virus (HAV) infection is typically not associated with kidney disease.

Observation:

  • A 43-year-old male with acute HAV infection developed persistent nephrotic syndrome (proteinuria, hypoalbuminemia, edema).
  • Renal biopsy revealed focal segmental glomerulosclerosis (FSGS).

Findings:

  • Acute HAV infection can manifest as FSGS, a form of nephrotic syndrome.
  • Prednisolone treatment improved the patient's nephrotic symptoms.

Implications:

  • Acute HAV infection should be considered in cases of new-onset nephrotic syndrome.
  • Persistent proteinuria or hypoalbuminemia in HAV patients warrants nephrology evaluation.

Keywords:
complicationextrahepaticfocal segmental glomerulosclerosishepatitis A virusproteinuria

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