SERS Immunosensors for Cancer Markers Detection

Area of Science:

• Analytical Chemistry
• Biomedical Engineering
• Oncology

Background:

• Early cancer diagnosis and monitoring are critical for patient survival and effective treatment.
• Accurate and sensitive detection of cancer biomarkers in biological fluids is paramount for diagnosis and prognosis.
• Nanomaterials and immunodetection have advanced sensitive biomarker detection methods.

Purpose of the Study:

• To review advancements in the immunochemical determination of cancer biomarkers using Surface-Enhanced Raman Spectroscopy (SERS).
• To present up-to-date works on single and multi-analyte cancer biomarker detection via SERS.
• To discuss future perspectives for SERS immunosensors in cancer marker detection.

Main Methods:

• Review of existing literature on immunoassays and SERS principles.
• Analysis of studies employing SERS immunosensors for cancer biomarker detection.
• Focus on nanostructured materials and immunoreagents for enhanced detection.

Main Results:

• SERS immunosensors combine nanostructured materials and immunoreagents for sensitive biomarker detection.
• Demonstrated success in detecting both single and multiple cancer biomarkers.
• Potential for point-of-care applications due to sensitive and accurate detection capabilities.

Conclusions:

• SERS immunosensors represent a promising technology for sensitive cancer biomarker detection.
• Continued advancements are expected to enhance their utility in clinical diagnostics.
• The field holds significant potential for improving early cancer detection and patient management.