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Fabrication Methods and Chronic In Vivo Validation of Mechanically Adaptive Microfluidic Intracortical Devices.

Youjoung Kim1,2, Natalie N Mueller1,2, William E Schwartzman1,2

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.

Micromachines
|May 27, 2023
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Summary

This study developed advanced neural probes using soft materials and drug delivery to reduce brain inflammation, improving device longevity for brain-computer interfaces and neuroscience research.

Keywords:
drug deliverymechanically adaptivemicrofabricationmicrofluidicneural interfacepolymer

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Area of Science:

  • Neuroscience
  • Biomaterials Science
  • Medical Devices

Background:

  • Intracortical neural probes are vital for neuroscience and brain-computer interfaces (BCIs).
  • Chronic implantation leads to neuroinflammation and probe failure.
  • Existing solutions focus on materials or therapies to mitigate inflammation.

Purpose of the Study:

  • To integrate a dynamically softening polymer substrate and microfluidic drug delivery within neural probes.
  • To minimize tissue strain and deliver neuroprotective agents at the probe-tissue interface.
  • To enhance the performance and longevity of intracortical neural probes.

Main Methods:

  • Optimized fabrication processes and device designs for mechanical properties, stability, and microfluidic function.
  • Incorporated microfluidic channels for localized drug delivery.
  • Conducted a six-week in vivo study in rats using antioxidant delivery.

Main Results:

  • Successfully delivered an antioxidant solution via microfluidic channels over six weeks.
  • A multi-outlet microfluidic design demonstrated superior reduction in inflammation markers.
  • The combined approach of soft materials and drug delivery showed promise for neuroprotection.

Conclusions:

  • A platform technology combining soft materials and localized drug delivery can reduce neural probe-induced inflammation.
  • This approach enhances neural probe performance and longevity for clinical applications.
  • Future studies can explore additional therapeutics to further improve chronic device function.