Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid hormone administration in irradiated patients.

E D Murphy, E F Scanlon, R M Garces

    Journal of Surgical Oncology
    |March 1, 1986
    PubMed
    Summary

    Thyroid hormone therapy (L-thyroxine) reduced nodules and abnormalities in patients previously exposed to radiation. This prospective study shows a significant benefit in preventing thyroid issues in high-risk individuals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cryoablation: A Minimally Invasive Alternative for Early-Stage Breast Cancer: 6-Year Outcomes of the FROST Clinical Trial.

    Annals of surgical oncology·2026
    Same author

    Measurement of the Positive Muon Anomalous Magnetic Moment to 127 ppb.

    Physical review letters·2025
    Same author

    Measurement of the Positive Muon Anomalous Magnetic Moment to 0.20 ppm.

    Physical review letters·2023
    Same author

    Vaccine hesitancy educational tools for healthcare providers and trainees: A scoping review.

    Vaccine·2022
    Same author

    Process and strategies for patient engagement and outreach in the Sickle Cell Disease (SCD) community to promote clinical trial participation.

    Journal of the National Medical Association·2022
    Same author

    Prevalence and Disparities in Folate and Vitamin B12 Deficiency Among Preschool Children in Guatemala.

    Maternal and child health journal·2021

    Area of Science:

    • Endocrinology
    • Oncology
    • Nuclear Medicine

    Background:

    • Patients with a history of radiation exposure in infancy or childhood are at increased risk for thyroid carcinoma.
    • Early detection and intervention are crucial for managing thyroid abnormalities in this high-risk population.

    Purpose of the Study:

    • To evaluate the efficacy of suppressive L-thyroxine therapy in preventing thyroid nodules and abnormalities in radiated patients.
    • To compare outcomes between radiated patients treated with L-thyroxine and a matched non-treated radiated group.

    Main Methods:

    • Randomized controlled trial in a recall clinic setting.
    • Prospective suppressive L-thyroxine therapy offered to a radiated group.
    • Matched comparison with a radiated, non-treated group.

    Related Experiment Videos

  • Average follow-up of over two years.

    • Main Results:

    • The L-thyroxine-treated radiated group developed fewer thyroid nodules.
    • A statistically significant reduction in palpable abnormalities was observed in the treated group.
    • Thyroid hormone therapy demonstrated a protective effect against radiation-induced thyroid changes.

    Conclusions:

    • Prospective suppressive L-thyroxine therapy is effective in reducing thyroid nodules and abnormalities in patients with a history of radiation exposure.
    • Early intervention with L-thyroxine can mitigate long-term risks of thyroid disease in radiated individuals.