Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adjuvant chemotherapy in Ewing's sarcoma.

S H Advani, D N Rao, K A Dinshaw

    Journal of Surgical Oncology
    |June 1, 1986
    PubMed
    Summary

    Adjuvant chemotherapy with vincristine, cyclophosphamide, and adriamycin significantly improved survival for localized Ewing's sarcoma patients. This treatment effectively controlled micrometastasis and residual disease, offering better outcomes than historical controls.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of atmospheric dust on phytoplankton dynamics and primary productivity in the tropical marine ecosystem of the Eastern Arabian Sea.

    Marine pollution bulletin·2025
    Same author

    Emerging severe acute respiratory syndrome coronavirus 2 variants and their impact on immune evasion and vaccine-induced immunity.

    Transactions of the Royal Society of Tropical Medicine and Hygiene·2024
    Same author

    RBD mutations at the residues K417, E484, N501 reduced immunoreactivity with antisera from vaccinated and COVID-19 recovered patients.

    Drug target insights·2024
    Same author

    Major sources of sinking particulate organic matter in the western Bay of Bengal.

    Marine environmental research·2024
    Same author

    ALTERATION OF AKT1-GSK3Β SIGNALING PATHWAY IN TRAUMA HEMORRHAGIC SHOCK PATIENTS.

    Shock (Augusta, Ga.)·2022
    Same author

    Impact of atmospheric dry deposition of nutrients on phytoplankton pigment composition and primary production in the coastal Bay of Bengal.

    Environmental science and pollution research international·2022

    Area of Science:

    • Pediatric Oncology
    • Medical Oncology
    • Cancer Research

    Background:

    • Localized Ewing's sarcoma presents a significant challenge in pediatric oncology.
    • Effective adjuvant treatment strategies are crucial for improving patient survival rates.

    Purpose of the Study:

    • To evaluate the efficacy of adjuvant chemotherapy with vincristine, cyclophosphamide, and adriamycin in patients with localized Ewing's sarcoma.
    • To compare survival outcomes with historical control data.

    Main Methods:

    • A cohort of 28 patients with localized Ewing's sarcoma received adjuvant chemotherapy.
    • Vincristine, cyclophosphamide, and adriamycin were administered as part of the chemotherapy regimen.
    • Life-table analysis was employed to assess disease-free survival at 3 years.

    Related Experiment Videos

    Main Results:

    • The study achieved a 55% disease-free survival rate at 3 years.
    • Historical control data indicated less than 10% long-term survival.
    • Adjuvant chemotherapy demonstrated control over both micrometastasis and local residual disease.

    Conclusions:

    • Adjuvant chemotherapy, including adriamycin, vincristine, and cyclophosphamide, significantly improves survival in localized Ewing's sarcoma.
    • This therapeutic approach is effective in managing both microscopic and local disease spread.
    • The findings support the use of this specific chemotherapy regimen as a standard of care.