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Central Nervous System Histoplasmosis: An Updated Insight
José Antonio Ramírez1, María Del Rocío Reyes-Montes1, Gabriela Rodríguez-Arellanes1
1Unidad de Micología, Departamento de Microbiología-Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), CDMX, Mexico City 04510, Mexico.
Pathogens (Basel, Switzerland)
|May 27, 2023
Summary
Histoplasmosis can affect the Central Nervous System (CNS), causing severe infections like meningitis and lesions. This review details the epidemiology, diagnosis, and treatment of CNS histoplasmosis.
Area of Science:
- Mycology
- Infectious Diseases
- Neurology
Background:
- Histoplasmosis is a systemic fungal infection caused by *Histoplasma capsulatum*.
- The Central Nervous System (CNS) can be involved, leading to severe and life-threatening conditions.
- CNS involvement presents with meningitis, focal lesions (abscesses, histoplasmomas), and spinal cord injuries.
Purpose of the Study:
- To provide updated data on Central Nervous System (CNS) histoplasmosis.
- To offer a focused perspective on the mycosis, its causative agent, and CNS manifestations.
- To review epidemiology, clinical forms, pathogenesis, diagnosis, and therapy for CNS histoplasmosis.
Main Methods:
- Literature review of updated data on *Histoplasma capsulatum* and CNS infections.
- Synthesis of information on epidemiology, clinical presentations, and pathogenesis.
- Compilation of current diagnostic and therapeutic strategies for CNS histoplasmosis.
Main Results:
- Central Nervous System (CNS) histoplasmosis is a severe mycosis caused by *Histoplasma capsulatum*.
- Clinical manifestations include meningitis, focal CNS lesions, and spinal cord injuries.
- Updated data on the pathogen, its spread, and disease progression are presented.
Conclusions:
- Central Nervous System (CNS) histoplasmosis requires accurate diagnosis and timely treatment.
- This review consolidates current knowledge to guide clinical practice and research.
- Understanding the multifaceted aspects of CNS histoplasmosis is crucial for managing this infection.
