Related Experiment Video
Updated: Jul 29, 2025
10:28
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
9.8K
First Report on Abnormal Renal Function in Acute Hepatitis E Genotype 1 Infection.
Amal A Elkhawaga1, Mohamed A El-Mokhtar1, Amal A Mahmoud2
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
Pathogens (Basel, Switzerland)
|May 27, 2023
Summary
Hepatitis E virus genotype 1 (HEV-1) can impair kidney function in some patients during acute infection. Kidney function tests (KFTs) returned to normal upon recovery, indicating reversible renal complications.
Area of Science:
- Virology
- Nephrology
- Hepatology
Background:
- Hepatitis E virus (HEV) infections, particularly genotypes 3 and 4, are associated with impaired renal function.
- The impact of HEV genotype 1 (HEV-1) on kidney function during the acute phase remains largely unknown.
Purpose of the Study:
- To investigate kidney function parameters in patients with acute HEV-1 infection.
- To identify factors associated with renal impairment in HEV-1 patients during the acute phase.
Main Methods:
- Serum kidney function tests (KFTs) were analyzed in 31 patients with acute HEV-1 infection (AHE).
- Patients were categorized based on normal versus abnormal KFTs.
- Demographic, laboratory, and clinical data were compared between groups.
Main Results:
- 16% of AHE patients exhibited abnormal KFTs during acute infection.
- Abnormal KFTs were associated with older age and lower albumin levels.
- Impaired kidney function resolved to normal levels during the recovery phase.
Conclusions:
- This is the first study to evaluate KFTs in patients during the acute phase of HEV-1 infection.
- Reversible kidney function impairment can occur in HEV-1 infections.
- Monitoring KFTs is recommended for patients with HEV-1 infections.
Related Concept Videos
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
41
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
41
01:22Acute Kidney Injury I: Introduction
39
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
39
01:29Acute Kidney Injury III: Clinical Manifestations
45
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
45
01:29Acute Kidney Injury II: Pathophysiology
37
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
37
01:24Serum Studies: Renal Function Tests
25
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
25
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
20
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
20