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Prescriptive Appropriateness: Inhospital Adherence to Proton Pump Inhibitors Deprescription Flow Chart.
Giammarco Baiardi1,2, Giulia Calvini1,2, Serena Panarello3
1Clinical Pharmacology Unit, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy.
Pharmaceuticals (Basel, Switzerland)
|May 27, 2023
Summary
Implementing a Proton Pump Inhibitor (PPI) deprescription flowchart in hospitals showed high prescriber adherence and few recurrence events. Clinical pharmacologist involvement enhanced this successful deprescribing strategy.
Area of Science:
- Pharmacology
- Internal Medicine
- Geriatrics
Background:
- Proton Pump Inhibitors (PPIs) use in polypharmacy is debated due to overprescription risks.
- Increased drug interactions and errors are associated with multiple medications.
Purpose of the Study:
- To evaluate the implementation of a PPI deprescription flowchart in hospital wards.
- To assess prescriber adherence and the impact of clinical pharmacologists on deprescribing.
Main Methods:
- An observational prospective study involving 98 patients (mean age 75.6 years).
- A validated PPI deprescription flowchart was implemented in internal medicine wards.
- Prescriber adherence and patient outcomes were monitored, with clinical pharmacologist support.
Main Results:
- 70.4% of patients followed the flowchart's deprescribing pathway.
- Low rates of symptomatic recurrence were observed.
- Clinical pharmacologist presence was linked to successful implementation.
Conclusions:
- Multidisciplinary management of PPI deprescribing protocols demonstrates high adherence in clinical practice.
- Guided deprescription strategies are effective in reducing PPI use and recurrence.
- Clinical pharmacologist support is a key factor for successful deprescribing initiatives.
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