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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Core-Shell Structured PLGA Particles Having Highly Controllable Ketoprofen Drug Release.

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This study demonstrates controllable drug release from poly(lactide-co-glycolide) (PLGA) nanoparticles using stabilizers like Pluronic F127 and Tween20. Stabilizer choice significantly impacts drug retention and release profiles for targeted delivery applications.

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Area of Science:

  • * Nanotechnology
  • * Materials Science
  • * Pharmaceutical Sciences

Background:

  • * Poly(lactide-co-glycolide) (PLGA) nanoparticles are investigated as drug delivery systems.
  • * Ketoprofen (KP) is used as a model non-steroidal anti-inflammatory drug.
  • * Stabilizers such as Tween20 (TWEEN) and Pluronic F127 (PLUR) are explored for particle formation.

Purpose of the Study:

  • * To design biocompatible colloidal carrier particles with controllable drug release.
  • * To investigate the influence of stabilizers on nanoparticle structure and drug release kinetics.
  • * To optimize PLGA nanoparticle formulation for enhanced drug delivery.

Main Methods:

  • * Nanoprecipitation method used for encapsulating ketoprofen (KP) in PLGA nanoparticles.
  • * Transmission Electron Microscopy (TEM) for characterizing core-shell structure.
  • * Optimization of drug concentration and stabilizer selection for stable colloids (~200-210 nm hydrodynamic diameter).

Main Results:

  • * Well-defined core-shell nanostructures were successfully formed.
  • * Encapsulation efficiency (EE%) ranged from 14-18%.
  • * Stabilizer molecular weight and structure significantly controlled drug release: Pluronic F127 (PLUR) resulted in ~20% retention, while Tween20 (TWEEN) yielded ~70% retention.
  • * Drug release was further tunable by adjusting PLGA hydrophilicity via monomer ratio.

Conclusions:

  • * Pluronic F127 provides steric stabilization (loose shell), leading to lower drug retention.
  • * Tween20 forms a more compact shell, resulting in higher drug retention.
  • * The choice of stabilizer and PLGA composition offers a versatile strategy for tuning drug release profiles in nanocarrier systems.