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Related Experiment Video

Updated: Jul 29, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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Responsive Microneedles as a New Platform for Precision Immunotherapy.

Xinyang Liu1,2, Haohao Song1,2, Tairan Sun3

  • 1Henan Institutes of Advanced Technology, Zhengzhou University, Zhengzhou 450052, China.

Pharmaceutics
|May 27, 2023
PubMed
Summary

Microneedles offer a novel approach for immunotherapy delivery directly to immune cells in the skin. Stimuli-responsive microneedles enhance treatment efficacy and reduce side effects, particularly for tumor immunotherapy.

Keywords:
controlled releaseimmunotherapymicroneedlesresponsivenessvaccine delivery

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Area of Science:

  • Biomedical Engineering
  • Immunology
  • Drug Delivery Systems

Background:

  • Microneedles represent a transdermal drug delivery system with unique advantages for immunotherapy.
  • They enable targeted delivery of immunotherapeutic agents to the epidermis and dermis, rich in immune cells.

Purpose of the Study:

  • To review the advancements in using stimuli-responsive microneedles for immunotherapy, with a focus on cancer treatment.
  • To examine the controllable administration and targeting capabilities of these advanced microneedle systems.

Main Methods:

  • Review of current literature on microneedle technology for immunotherapy.
  • Analysis of stimuli-responsive mechanisms (pH, ROS, enzymes, light, temperature, mechanical force) for controlled drug release.
  • Examination of microneedle design for enhanced immune response and reduced systemic toxicity.

Main Results:

  • Stimuli-responsive microneedles can achieve precise drug delivery and controlled release in the skin.
  • These systems demonstrate potential to enhance immunotherapy efficacy by targeting abundant immune cells.
  • Multifunctional microneedles can mitigate systemic adverse effects.

Conclusions:

  • Microneedles are a promising platform for advanced immunotherapy, particularly for tumors.
  • Stimuli-responsive microneedle systems offer enhanced control over drug release and targeting.
  • Further research into limitations and controllable administration is crucial for clinical translation.