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Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
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Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release.

Jiaqi Weng1,2, Alain Durand2, Stéphane Desobry1

  • 1Université de Lorraine, LIBio, F-54000 Nancy, France.

Pharmaceutics
|May 27, 2023
PubMed
Summary

Chitosan (CS) particulate carriers offer versatile drug delivery. Optimizing CS particle preparation enables tailored drug release kinetics for advanced delivery systems.

Keywords:
capsuleschitosancontrolled releaseparticles

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Chitosan (CS) is a promising biopolymer for drug delivery applications.
  • Particulate carriers made from CS have demonstrated significant scientific and commercial potential.

Purpose of the Study:

  • To review the state-of-the-art in using chitosan for particulate drug delivery carriers.
  • To detail the relationship between preparation processes, particle characteristics, and drug release kinetics.
  • To explore the potential for designing "on-demand" drug delivery systems.

Main Methods:

  • Review of existing literature on chitosan-based particulate carriers.
  • Analysis of preparation techniques and their influence on particle size and structure.
  • Examination of characterization methods for particle properties.
  • Discussion of mathematical models for drug release kinetics.

Main Results:

  • Chitosan particle size and structure significantly impact drug release patterns (zero-order, multi-pulsed, pulse-triggered).
  • Preparation methods critically influence particle characteristics and subsequent release properties.
  • Mathematical models are essential for understanding release mechanisms and optimizing carrier design.

Conclusions:

  • Chitosan particulate carriers can be engineered for controlled and targeted drug delivery.
  • A "reverse strategy" allows designing preparation processes based on desired release profiles.
  • Further research can lead to novel "on-demand" drug delivery devices.