Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting druggable ion channels to harness cancer cell mechanobiology for therapy.

Developmental cell·2026
Same author

The Effect of Aza-Glycine Substitution on the Internalization of Dabcyl-Containing Short Oligoarginine.

Biomedicines·2026
Same author

Penetratin an Old Player in the Field of Cell-Penetrating Peptides Is in New Custom-Effect of Aromatic Non-Natural Amino Acid Substitutions.

Pharmaceutics·2026
Same author

Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release.

Cell death and differentiation·2026
Same author

Mitochondria-Targeting Moieties Based on N-Tethered Pyridinium Cations.

Angewandte Chemie (International ed. in English)·2026
Same author

Microfluidic compartmentalization reveals that ferrostatin-1 restores directional mitochondrial transport in Aβ-challenged neurons.

Lab on a chip·2026

Related Experiment Video

Updated: Jul 29, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.1K

DA7R: A 7-Letter Zip Code to Target PDAC.

Sofia Parrasia1, Andrea Rossa2, Nicola Roncaglia2,3

  • 1Department of Biology, University of Padova, Viale G. Colombo 3, 35131 Padova, Italy.

Pharmaceutics
|May 27, 2023
PubMed
Summary
This summary is machine-generated.

Researchers explored using A7R peptide conjugates for pancreatic cancer targeting. The A7R peptide successfully delivered anticancer compounds to pancreatic ductal adenocarcinoma cells, showing promise for improved cancer therapy.

Keywords:
A7R peptidePAPTPneuropilin-1 (NRP-1)pancreatic ductal adenocarcinoma (PDAC)vascular endothelial growth factor receptor-2 (VEGFR2)

More Related Videos

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
06:29

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Published on: March 3, 2021

5.6K
DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
12:24

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

Published on: July 21, 2014

16.8K

Related Experiment Videos

Last Updated: Jul 29, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.1K
Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
06:29

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Published on: March 3, 2021

5.6K
DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
12:24

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

Published on: July 21, 2014

16.8K

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Delivery

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable cancer.
  • Novel therapeutic strategies are urgently needed for PDAC treatment.
  • Peptides offer targeted delivery by binding to cancer cell surface proteins.

Purpose of the Study:

  • To evaluate A7R peptide-drug conjugates as a targeting strategy for PDAC.
  • To assess the potential of A7R to deliver the anticancer compound PAPTP to PDAC cells.

Main Methods:

  • Designed A7R peptide derivatives (DA7R, cA7R) with bioreversible linkers and PAPTP cargo.
  • Introduced a tetraethylene glycol chain to enhance solubility.
  • Investigated uptake of fluorescent DA7R conjugates and PAPTP-DA7R derivatives in PDAC cell lines.

Main Results:

  • Uptake of DA7R conjugates correlated with neuropilin-1 (NRP-1) and VEGFR2 expression in PDAC cells.
  • The PAPTP-DA7R derivative demonstrated targeted delivery to PDAC cells.

Conclusions:

  • A7R-drug conjugates show potential for targeted drug delivery in PDAC.
  • This approach could enhance therapeutic efficacy and reduce side effects.
  • Further development of A7R conjugates for PDAC therapy is warranted.