Formulation Strategies of Nanosuspensions for Various Administration Routes

Area of Science:

• Pharmaceutical Sciences
• Nanotechnology
• Drug Delivery

Background:

• Nanosuspensions (NSs) are colloidal systems of nanosized drug particles.
• They offer enhanced solubility and dissolution for poorly water-soluble drugs.
• NSs can improve drug pharmacokinetics, efficacy, and safety across various administration routes.

Purpose of the Study:

• To review the impact of formulation and process parameters on NS properties.
• To highlight recent advances and strategies in NS development.
• To discuss practical considerations for NS application in different routes.

Main Methods:

• Discussion of top-down (e.g., milling, homogenization) and bottom-up (e.g., precipitation, sono-precipitation) preparation methods.
• Exploration of formulation components, including stabilizers like surfactants and polymers.
• Consideration of post-production processes (e.g., freeze-drying, spray-drying) for solid dosage forms.

Main Results:

• Particle size and surface area are key to enhanced drug solubility and dissolution.
• Stabilizer selection and ratio are critical for NS formulation stability.
• Optimization of components, methods, and parameters is essential for intended use.

Conclusions:

• NSs represent a promising nanopharmaceutical strategy for improving drug delivery.
• Careful control over formulation and processing is vital for successful NS development.
• This review provides insights into optimizing NSs for diverse pharmaceutical applications.