Related Experiment Video
Updated: Jul 29, 2025
09:30
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
19.6K
Renal MRI: From Nephron to NMR Signal
Octavia Bane1,2, Erdmann Seeliger3, Eleanor Cox4
1Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Journal of Magnetic Resonance Imaging : JMRI
|May 27, 2023
Summary
Magnetic Resonance Imaging (MRI) biomarkers offer promising advancements for diagnosing and monitoring renal diseases. This summary highlights efforts to improve MRI
Area of Science:
- Medical Imaging
- Nephrology
- Biophysics
Background:
- Renal diseases present a substantial socio-economic burden, necessitating improved diagnostic and prognostic tools.
- Magnetic Resonance Imaging (MRI) biomarkers are crucial for early detection, disease progression monitoring, and treatment assessment in kidney diseases.
- Despite advancements in renal MRI, a need persists for greater pathophysiological specificity to enhance clinical utility.
Purpose of the Study:
- To summarize presentations from the ISMRM 2022 Member Initiated Symposium on renal MRI.
- To bridge the gap between imaging scientists, clinicians, and nephrologists by educating on renal (patho)physiology and clinical needs.
- To explore the connection between MRI parameters and renal physiology, and to present innovations in renal MRI surrogates for clinical decision-making.
Main Methods:
- Review and synthesis of presentations from a dedicated symposium on renal MRI.
- Educational content on renal (patho)physiology and clinical demands from nephrologists.
- Discussion of current and next-generation MR surrogates for renal structure and function assessment.
Main Results:
- Elucidation of the link between specific MRI parameters and renal physiological processes.
- Presentation of leading MR surrogates for assessing renal structure and function.
- Demonstration of the potential for clinically meaningful renal characterization using advanced MRI markers.
Conclusions:
- Enhanced understanding of renal (patho)physiology is vital for advancing MRI biomarkers.
- Cross-disciplinary collaboration is essential to connect biophysics with clinical nephrology for novel applications.
- Future efforts should focus on leveraging unique renal physiology for improved diagnostics and prognostics in kidney disease.
Related Concept Videos
01:24Magnetic Resonance Imaging
5.3K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.3K
01:27Imaging Studies IV: Magnetic Resonance Imaging
37
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
37
01:25Applications Of NMR In Biology
3.8K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
3.8K
01:07Nuclear Magnetic Resonance (NMR): Overview
2.7K
Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
2.7K
01:14NMR Spectrometers: Resolution and Error Correction
740
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
740
01:17NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences
851
A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
851