Cortex-wide neural dynamics predict behavioral states and provide a neural basis for resting-state dynamic functional
Somayeh Shahsavarani1, David N Thibodeaux2, Weihao Xu2
1Mortimer B. Zuckerman Mind Brain Behavior Institute and Department of Biomedical Engineering, Columbia University, New York, NY, USA; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Cell Reports
|May 27, 2023
Summary
This study reveals that brain-wide neuronal activity fluctuations, not just hemodynamics, drive dynamic resting-state functional MRI (fMRI) patterns. These neural fluctuations are crucial for understanding brain states during rest.
Area of Science:
- Neuroscience
- Systems Neuroscience
- Cognitive Neuroscience
Background:
- Resting-state functional magnetic resonance imaging (fMRI) reveals dynamic brain networks, but hemodynamic signals complicate interpretation.
- Real-time neuronal recordings show brain-wide activity fluctuations obscured by traditional averaging.
Purpose of the Study:
- To reconcile fMRI findings with direct neuronal recordings.
- To investigate the neural basis of dynamic brain network correlations during spontaneous behavior.
Main Methods:
- Simultaneous wide-field optical mapping of pan-cortical neuronal and hemodynamic activity in awake mice.
- Analysis of brain-wide activity patterns and interregional correlations during rest and behavior.
Main Results:
- Neuronal activity patterns, especially during quiet rest, significantly contribute to interregional correlations.
- Dynamic correlation shifts align with changes in arousal state.
- Simultaneously recorded hemodynamics show similar brain-state-dependent correlation shifts.
Conclusions:
- Provides a neural basis for dynamic resting-state fMRI observations.
- Emphasizes the critical role of brain-wide neuronal fluctuations in understanding brain states.
Keywords:
CP: Neurosciencearousalbrain statecalcium imagingdynamic functional connectivityfunctional topographyneurovascular couplingreal-time behaviorresting statespatiotemporal correlationwide-field optical mapping
