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Published on: August 14, 2019
A Comparative Study between Abrus cantoniensis and Abrus mollis: Flavonoids Profiles by UPLC-Q-TOF-MS and
Zhike Liang1, Zhixia Chen2, Xianmei Xue1
1Center of New Drug Research and Development/Guangdong Provincial Key Laboratory of New Drug Dosage Form/Key Laboratory of Modern Chinese Medicine, Department of Education of Guangdong Province/Traditional Chinese Medicine Preparation Laboratory, National Administration of Traditional Chinese Medicine (LevelIII), Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Abstract:
Abrus mollis (MJGC) has been used as a substitute herb for Abrus cantoniensis (JGC) in China. However, an in-depth comparison on their key metabolites and the mechanism of anti-inflammation between these two is not available. In this report, high pressure liquid chromatography equipped with mass spectrometry was applied to capture their flavonoid profiles; transcriptomics was adopted to analyze their anti-inflammatory mechanisms. The results showed that the main flavonoids in MJGC were vicenin-2, schaftoside and isoschaftoside, while those in JGC were vicenin-1 isomer and schaftoside isomer. The anti-inflammatory activity of JGC was slightly stronger than that of MJGC. The number of differential expression genes regulated by JGC was significantly higher than MJGC. JGC regulated 151 (42 up and 109 down) of inflammation related genes, while MJGC regulated 58 (8 up and 50 down) of inflammation related genes. The results of this study provided scientific evidence and guidance for the substitution of MJGC and JGC.
