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Changes in prevalence of non-optimal neurological condition between 6.5 and 12 years in children born extremely

Daniela Nosko1, Lina Broström2, Jenny Bolk3

  • 1Paediatric Department, Örebro University Hospital, Örebro, Sweden.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|May 27, 2023
PubMed

Insights

Children born extremely preterm (EPT) show a higher prevalence of non-optimal neurological conditions and impaired motor function up to adolescence. While neurological conditions improve with age, they remain more common in EPT children compared to term-born peers.

Area of Science:

  • Pediatric Neurology
  • Developmental Pediatrics
  • Neuroscience

Background:

  • Extremely preterm (EPT) birth is associated with increased risks for neurodevelopmental challenges.
  • Longitudinal assessment of neurological condition and motor function in EPT children is crucial for understanding developmental trajectories.
  • Non-optimal neurological condition can impact various aspects of a child's development and daily functioning.

Purpose of the Study:

  • To determine the prevalence of non-optimal neurological conditions in children born extremely preterm (EPT) up to early adolescence.
  • To investigate the association between neurological condition and motor function in EPT children.
  • To examine changes in neurological condition between 6.5 and 12 years of age.

Main Methods:

  • Prospective cohort study including 106 children (62 EPT, 44 term-born controls).
  • Neurological condition assessed at 6.5 and 12 years using four domains of the Touwen Neurological Examination.
  • Motor function evaluated using the Movement Assessment Battery for Children 2nd edition (MABC-2).

Main Results:

  • At 12 years, 44% of EPT children had a non-optimal neurological condition, compared to 9% of controls (p<0.001).
  • The prevalence of non-optimal neurological conditions in EPT children decreased from 37 to 27 between 6.5 and 12 years (p=0.007).
  • EPT children with non-optimal neurology at 12 years had significantly lower MABC-2 scores across total and subscale measures (manual dexterity, aiming/catching, balance).

Conclusions:

  • The prevalence of non-optimal neurological conditions decreases with age but remains significantly higher in EPT children at 12 years.
  • Neurological impairments in EPT children are associated with reduced motor function.
  • Early identification and intervention for neurological and motor deficits in EPT populations are warranted.
Abstract

Keywords:
Extremely pretermMinor neurological dysfunctionMotor functionNeurodevelopmentNeurological dysfunctionPrevalence

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