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Gastric cancer treatment: recent progress and future perspectives
Wen-Long Guan1,2, Ye He1,2, Rui-Hua Xu3,4
1Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
Journal of Hematology & Oncology
|May 27, 2023
Summary
Systemic treatments for gastric cancer (GC) are advancing, with chemotherapy, targeted therapy, and immunotherapy showing promise. Biomarker-driven approaches personalize treatment for better outcomes in resectable and metastatic GC.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Gastric cancer (GC) is a prevalent malignancy often diagnosed at advanced stages.
- Subtle early symptoms and low screening rates contribute to late diagnosis.
- Systemic therapies for GC have seen significant recent advancements.
Purpose of the Study:
- To review research progress in systemic treatments for gastric cancer.
- To discuss current individualized treatment strategies based on molecular biomarkers.
- To present future perspectives in gastric cancer therapy.
Main Methods:
- Systematic review of recent research on systemic therapies for gastric cancer.
- Analysis of advancements in chemotherapy, targeted therapy, and immunotherapy.
- Evaluation of biomarker-driven classification for personalized treatment.
Main Results:
- Perioperative chemotherapy is standard for resectable GC.
- Targeted therapy and immunotherapy are being investigated for perioperative/adjuvant settings.
- Immunotherapy and biomarker-directed therapies show recent advancements for metastatic GC.
- Molecular biomarkers like PD-L1, MSI, and HER2 aid in patient stratification for immunotherapy and targeted therapy.
Conclusions:
- Personalized treatment strategies are emerging for gastric cancer.
- Molecular diagnostics are crucial for characterizing GC and identifying therapeutic targets.
- Continued research into systemic treatments and targeted therapies holds promise for improved patient outcomes.
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