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Related Concept Videos

Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

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Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
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Nitrogen is an essential element in biological systems, forming a crucial component of proteins, nucleic acids, and other cellular constituents. Many bacteria and archaea acquire nitrogen in the form of nitrate (NO₃⁻) or ammonia (NH₃), which are then assimilated into biomolecules through specific enzymatic pathways.Assimilatory Nitrate ReductionWhen nitrate enters the cell, it undergoes a two-step reduction process known as assimilatory nitrate reduction. Initially, the enzyme...
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Updated: Jul 28, 2025

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Strategic nutrient sourcing for biomanufacturing intensification.

Kimia Noroozi1, Laura R Jarboe1

  • 1Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.

Journal of Industrial Microbiology & Biotechnology
|May 28, 2023
PubMed
Summary

Optimizing nutrient sources in bioprocesses, including waste streams, can significantly improve product yields and economic viability. This approach enhances sustainability by reducing reliance on fossil fuels and depleting resources.

Keywords:
BioprocessCarbonCorn steep liquorNitrogenNutrient sourcingPhosphorous

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Area of Science:

  • Biotechnology and Bioprocess Engineering
  • Industrial Microbiology
  • Sustainable Chemistry

Background:

  • Economically viable bioprocesses are crucial for reducing petroleum dependence and enhancing agricultural value.
  • Microbial engineering has advanced, but growth medium composition's impact on cost and performance is understudied.
  • Utilizing waste streams like corn steep liquor is key to sustainable biomanufacturing.

Purpose of the Study:

  • To highlight the significant, yet undervalued, impact of nutrient sourcing and adjustments on bioprocess performance and economics.
  • To review strategies for optimizing micronutrient utilization for improved product titers.
  • To emphasize the potential of waste stream valorization in biomanufacturing.

Main Methods:

  • Review of literature on process-specific nutrient optimizations.
  • Analysis of case studies demonstrating twofold or greater increases in product titers.
  • Discussion of sustainable nutrient alternatives (e.g., urea, struvite).

Main Results:

  • Specific micronutrient adjustments have demonstrated the potential to double product titers.
  • Strategic nutrient sourcing can substantially improve bioprocess metrics.
  • The mechanisms behind nutrient optimization effects are often unexplored, limiting generalizability.

Conclusions:

  • Thoughtful nutrient sourcing and adjustment are powerful, underutilized tools for bioprocess improvement.
  • Integrating waste streams and sustainable nutrient alternatives enhances economic viability and environmental impact.
  • Further research into nutrient-mechanism interactions is needed to generalize findings across bioprocesses.