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Updated: Jul 28, 2025

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When Alzheimer's is LATE: Why Does it Matter?

Peter T Nelson1, Julie A Schneider2, Gregory A Jicha3

  • 1Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY.

Annals of Neurology
|May 28, 2023
PubMed
Summary
This summary is machine-generated.

Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects 25% of older adults, causing memory loss often misdiagnosed as Alzheimer's disease (AD). Early LATE recognition is crucial for accurate diagnosis and treatment.

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Area of Science:

  • Neurology
  • Neuroscience
  • Geriatrics

Background:

  • Accurate dementia diagnosis is vital for effective treatment.
  • Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a common condition.
  • LATE symptoms can mimic Alzheimer's disease (AD).

Purpose of the Study:

  • To highlight the clinical significance of recognizing LATE.
  • To differentiate LATE from Alzheimer's disease based on underlying pathology.
  • To provide guidance on LATE diagnosis and management.

Main Methods:

  • Review of current literature on LATE and AD.
  • Analysis of clinical signs, symptoms, and diagnostic markers.
  • Discussion of neuropathological differences (TDP-43 vs. Aβ amyloid/tau).

Main Results:

  • LATE affects approximately 25% of older adults.
  • LATE presents with an amnestic syndrome, often confused with AD.
  • Distinct protein aggregates characterize LATE (TDP-43) and AD (Aβ amyloid/tau).

Conclusions:

  • Clinical recognition of LATE is essential for accurate dementia diagnosis.
  • Understanding LATE's distinct pathology is key, even when co-occurring with AD.
  • This review offers insights for physicians, patients, and families regarding LATE.