Fate and occurrence of indoxacarb during radish cultivation for multi-risk assessment

Agrochemical indoxacarb is an important tool for selective pest control in radish that be consumed globally. A rapid and sensitive analytical method UHPLC-MS/MS was developed for tracing indoxacarb in radish leaves and roots with LOQ of 0.001 mg/kg and RT within 2 min, which were confirmed the satisfied storage stability of indoxacarb in radish matrixes with degradation rates less than 30 %. The occurrence, pharmacokinetics dissipation and concentration variation of indoxacarb were reflected by the original deposition of 2.23-4.12 mg/kg, half-lives of 2.6-8.0 d and terminal magnitude of 0.17 × 10^-2-25.46 mg/kg in radish, and the influencing factors were further illustrated in terms of climate factors, crop cultivars and soil properties. The highest residues of indoxacarb were 25.46 mg/kg in leaves and 0.12 mg/kg in roots, which were higher than international maximum residue limits. A probabilistic model, as well as deterministic model, were introduced to evaluated the health risks of indoxacarb offering a better description for uncertainty. The total chronic dietary risk values of indoxacarb were 146.961-482.065 % in 12 registered crops, of which ADI % in radish was accounted for 19.8 % with risk dilution effects. The unacceptable acute dietary risks of 121.358-220.331 % were observed at 99.9th percentile, whereas the high-potential non-carcinogenic effects were observed over 90th percentile (105.035-1121.943 %). The health risks should be continuously emphasized given the increasing applications and persistent characteristics of indoxacarb, which is vital to protect the human population from hazardous effects, particularly for vulnerable children.