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Related Experiment Video

Updated: Jul 28, 2025

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Diffusion and Perfusion Imaging in Rectal Cancer Restaging.

Vincenza Granata1, Roberta Fusco2, Sergio Venazio Setola1

  • 1Division of Radiology, "Istituto Nazionale Tumori IRCCS Fondazione Pascale - IRCCS di Napoli", Naples, Italy.

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|May 28, 2023
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Summary

Magnetic resonance imaging (MRI) accurately assesses tumor response after neoadjuvant radiochemotherapy (n-CRT), correlating radiological tumor regression grade (mrTRG) with pathologic tumor regression grade (pTRG) for better patient management.

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Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Assessing tumor response post-neoadjuvant radiochemotherapy (n-CRT) is crucial for patient stratification and treatment management.
  • Histopathology is the gold standard, but advancements in magnetic resonance imaging (MRI) enhance response evaluation accuracy.

Purpose of the Study:

  • To evaluate the role of MRI in assessing tumor response after n-CRT.
  • To correlate radiological tumor regression grade (mrTRG) with pathologic tumor regression grade (pTRG).
  • To highlight the utility of functional MRI techniques for early prediction of therapeutic efficacy.

Main Methods:

  • Utilized magnetic resonance imaging (MRI) for tumor response assessment.
  • Calculated radiological tumor regression grade (mrTRG) from MRI data.
  • Included functional MRI techniques such as diffusion-weighted MRI (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI).

Main Results:

  • MRI provides an accurate radiological tumor regression grade (mrTRG).
  • mrTRG shows a correlation with the established pathologic tumor regression grade (pTRG).
  • Functional MRI parameters, including DW-MRI and DCE-MRI, show potential for early prediction of treatment response.

Conclusions:

  • MRI is a valuable tool for assessing tumor response after n-CRT.
  • The radiological tumor regression grade (mrTRG) derived from MRI is a reliable indicator.
  • Functional MRI techniques offer promising capabilities for predicting therapy efficacy in clinical practice.