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Related Concept Videos

The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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Related Experiment Video

Updated: Jul 28, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Research Progress of BAP1 in Structure, Function, and Cancer.

Wei-Tao Lu1, Meng-Ru Li1, Yi-Bo Yang1

  • 1College of Marine and Environmental Sciences, Tianjin University of Science and Technology, Tianjin, 300457, China.

Protein and Peptide Letters
|May 29, 2023
PubMed
Summary

BRCA-associated protein 1 (BAP1) is a key enzyme involved in regulating cell functions like DNA repair. Mutations in BAP1 are linked to cancer development, highlighting its role in molecular pathogenesis.

Keywords:
BAP1cancerclinical valueepigenetic regulationhydrolasesubiquitination

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Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Cancer remains a leading global cause of death, with current treatments often limited to cellular and tissue levels.
  • Understanding cancer pathogenesis at the molecular level is crucial for developing effective regulatory strategies.
  • BRCA-associated protein 1 (BAP1) is an E3 ubiquitin ligase implicated in various cellular processes.

Purpose of the Study:

  • To review the fundamental structure and cellular functions of BAP1.
  • To elucidate the role of BAP1 in the development and progression of cancer.
  • To discuss cancer-associated mutations within the BAP1 gene.

Main Methods:

  • Literature review of BAP1's molecular functions.
  • Analysis of BAP1's involvement in cancer pathogenesis.
  • Examination of BAP1 mutations and their clinical relevance.

Main Results:

  • BAP1, encoded by the BAP1 gene, is a 729-amino acid ubiquitination enzyme.
  • BAP1 regulates intracellular functions including transcription, epigenetics, and DNA damage repair.
  • Dysregulation and mutations in BAP1 are associated with altered cell cycle and proliferation, contributing to carcinogenesis.

Conclusions:

  • BAP1 plays a critical role in maintaining cellular homeostasis and preventing cancer.
  • Understanding BAP1's function and mutation landscape is vital for targeted cancer therapies.
  • Further research into BAP1-mediated pathways may unlock new avenues for cancer treatment.