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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Coronary Artery Disease IV: Preventive Measures01:26

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Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Related Experiment Video

Updated: Jul 28, 2025

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
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Decrease in osteoporotic fracture in the western Kitakyushu region by the STOP-Fx study.

Yoshiaki Yamanaka1, Satoshi Ikeda2, Eiji Hatakeyama3

  • 1Department of Orthopedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-Ku, Kitakyushu, 807-8555, Japan. yamanaka@med.uoeh-u.ac.jp.

Journal of Bone and Mineral Metabolism
|May 29, 2023
PubMed
Summary
This summary is machine-generated.

The Seamless Treatment of Osteoporosis against Fractures (STOP-Fx) study reduced osteoporotic fracture surgeries. The study also increased osteoporosis treatment rates, indicating improved patient management and fracture prevention.

Keywords:
FractureOsteoporosisSTOP-Fx studyTherapeutic intervention

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Area of Science:

  • Gerontology
  • Orthopedics
  • Public Health

Background:

  • The Seamless Treatment of Osteoporosis against Fractures (STOP-Fx) study was initiated to provide and continue therapeutic interventions for registered patients with osteoporotic fractures.
  • Osteoporotic fractures pose a significant health burden, necessitating effective treatment strategies.

Purpose of the Study:

  • To evaluate the impact of the STOP-Fx study on reducing osteoporotic fracture surgeries.
  • To assess the intervention rate of osteoporosis treatment among enrolled patients.
  • To determine the incidence, timing, and associated factors of secondary fractures and loss to follow-up.

Main Methods:

  • Prospective study involving women with osteoporotic fractures across six hospitals in the Kitakyushu area (October 2016 - December 2018).
  • Data collection for primary and secondary outcomes occurred from October 2018 to December 2020.
  • Primary outcome: number of surgeries for osteoporotic fractures post-intervention. Secondary outcomes: osteoporosis treatment rates, secondary fracture incidence, and factors influencing fractures and follow-up.

Main Results:

  • A decrease in osteoporotic fracture surgeries was observed post-STOP-Fx study initiation (813 in 2017 to 683 in 2021).
  • Of 279 untreated patients at enrollment, 91% received osteoporosis treatment by 24 months.
  • 28 secondary fractures occurred, linked to elevated tartrate-resistant acid phosphatase-5b and reduced lumbar spine bone mineral density.

Conclusions:

  • The STOP-Fx study likely contributed to a reduction in osteoporotic fractures in the Kitakyushu region.
  • Sustained therapeutic interventions are crucial for managing osteoporosis and preventing fractures.
  • The study highlights the importance of monitoring treatment adherence and relevant biomarkers for fracture risk.