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    A new universal synthetic aperture (SA) imaging sequence enables high-quality B-mode, motion, and flow imaging from a single dataset. This approach simplifies ultrasound acquisition for various applications, including super-resolution imaging.

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    Area of Science:

    • Ultrasound imaging
    • Medical imaging physics

    Background:

    • Synthetic aperture (SA) imaging offers both anatomic and functional visualization.
    • Current SA imaging requires distinct sequences for B-mode and functional (e.g., flow) imaging.
    • Optimizing sequences for B-mode (high contrast) and flow (velocity estimation) differs significantly.

    Purpose of the Study:

    • To develop and validate a single, universal sequence for linear array SA imaging.
    • To achieve high-quality B-mode, motion, and flow estimates with one sequence.
    • To enable super-resolution imaging from the same data acquisition.

    Main Methods:

    • Implemented an optimized pulse inversion (PI) sequence with interleaved positive/negative pulse emissions.
    • Utilized 2x12 virtual sources, distributed and permuted for flow estimation (4, 8, or 12 sources).
    • Tested on linear array probes with Verasonics Vantage 256 and SARUS scanners, achieving high frame rates (208 Hz, 5000 images/sec recursively).

    Main Results:

    • Demonstrated high-quality linear and nonlinear B-mode images.
    • Achieved accurate motion and flow velocity estimates for both high and low velocities.
    • Successfully generated super-resolution images (SRI) from the same dataset.
    • Acquired data from a carotid artery phantom and a rat kidney, showcasing diverse imaging modes retrospectively.

    Conclusions:

    • A single, universal SA sequence can effectively produce diverse ultrasound imaging modalities.
    • This unified approach simplifies data acquisition and enables retrospective analysis of multiple parameters.
    • The developed sequence holds potential for advanced quantitative ultrasound imaging and super-resolution applications.