Exerkines and redox homeostasis.
Elisa Félix-Soriano1, Kristin I Stanford2
1Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH, USA.
Redox Biology
|May 29, 2023
Summary
Exercise physiology research highlights exerkines, signaling molecules that mediate exercise benefits. This review explores how exerkines interact with redox biology to improve health and exercise adaptations.
Area of Science:
- Exercise Physiology
- Redox Biology
- Molecular Biology
Background:
- Exercise physiology research is expanding due to the discovery of circulating factors called exerkines.
- Exerkines are secreted during exercise and mediate its systemic and tissue-specific effects.
- While metabolic roles of exerkines are known, their impact on redox signaling is increasingly recognized.
Purpose of the Study:
- To review the current evidence on the interplay between redox biology and exerkine actions.
- To elucidate the role of exerkines in modulating redox homeostasis and cellular stress responses.
- To highlight the significance of exerkines in exercise adaptations involving redox signaling.
Main Methods:
- Literature review of studies investigating exerkines and redox biology.
- Analysis of research on exerkine secretion and function during exercise.
- Synthesis of findings on exerkine-mediated redox signaling pathways.
Main Results:
- Exerkines play a crucial role in regulating redox signaling and homeostasis.
- They mediate the body's response to oxidative stress, improving health outcomes.
- Exerkines contribute to exercise adaptations by integrating redox signaling.
Conclusions:
- Exerkines are key mediators linking exercise to improved health and stress resilience.
- The cross-talk between exerkines and redox biology is fundamental to exercise physiology.
- Targeting exerkine-redox interactions offers potential for therapeutic interventions in disease.
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