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[Human hemoglobin: polymorphism, neutrality of variants, evolutionary aspect].

V A Spivak

    Molekuliarnaia Biologiia
    |May 1, 1986
    PubMed
    Summary

    Human hemoglobin polymorphism analysis integrates multiple data types to classify variants. Homeostasis and compensatory reactions are crucial for resistance against mutant hemoglobins, influencing molecular evolution.

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    Area of Science:

    • Integrative analysis of human hemoglobin polymorphism.
    • Utilizes populational genetics, hematological, physiological, protein chemistry, and molecular biology data.

    Context:

    • Human hemoglobin variants are classified as widely common, less common, or rare based on their contribution to polymorphism.
    • Homeostasis and compensatory reactions are vital for human body resistance against mutant hemoglobins.

    Purpose:

    • To analyze human hemoglobin polymorphism using an integrated approach.
    • To explore the role of local conformational mobility in creating neutral protein variants.
    • To differentiate between truly neutral and pseudoneutral protein variants.

    Summary:

    • A hypothesis suggests increased local conformational mobility contributes to neutral protein variants.
    • Truly neutral variants are not subject to selection, while pseudoneutral variants may be.
    • Compensated heterozygotes with neutral/pseudoneutral variants can develop new protein functions.

    Impact:

    • The study proposes a distinction between truly neutral and pseudoneutral variants, impacting evolutionary theory.
    • It suggests protein evolution progresses from neutrality towards selectionism.
    • Current human hemoglobin polymorphism reflects the protein's current molecular evolution stage.

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