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Stereotactic Radiotherapy or Whole-Brain Irradiation Plus Simultaneous Integrated Boost After Resection of Brain
Dirk Rades1, Leonie Johannwerner2, Nathan Y Yu3
1Department of Radiation Oncology, University of Lübeck, Lübeck, Germany; dirk.rades@uksh.de.
Anticancer Research
|May 29, 2023
Summary
Fractionated stereotactic radiotherapy (FSRT) and whole-brain irradiation plus simultaneous integrated boost (WBI+SIB) offer similar survival after brain metastases resection. Treatment choice may depend on potential toxicity and patient factors like single metastasis.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Post-operative radiotherapy is standard for resected brain metastases.
- Fractionated stereotactic radiotherapy (FSRT) and whole-brain irradiation plus simultaneous integrated boost (WBI+SIB) are common post-operative approaches.
Purpose of the Study:
- To compare outcomes of FSRT alone versus WBI+SIB after brain metastases resection.
- To identify predictors of local control, distant brain control, and overall survival.
Main Methods:
- Retrospective analysis of 44 patients treated with FSRT (n=32) or WBI+SIB (n=12) post-resection.
- Evaluation of 12 factors for impact on local control, distant brain control, and overall survival.
Main Results:
- Single brain metastasis was linked to better local and distant brain control.
- Longer time to radiotherapy, single metastasis, and Karnofsky performance score >80 predicted improved overall survival.
- WBI+SIB demonstrated a trend towards superior distant brain control.
Conclusions:
- Identified independent predictors for outcomes following FSRT or WBI+SIB for resected brain metastases.
- Similar survival rates suggest toxicity is a key consideration in treatment selection.
