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Synthesis and Characterization of Functionalized Metal-organic Frameworks

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Published on: September 5, 2014

Silane-Functionalized Metal-Organic Frameworks for Stimuli-Responsive Drug Delivery Systems: A New Universal

Xingkun Luan¹, Zehong Xiang², Jiangtao Dong¹

¹Key Laboratory of Mesoscopic Chemistry (Ministry of Education), State Key Laboratory of Coordination Chemistry, and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People's Republic of China.

ACS Applied Materials & Interfaces

|May 29, 2023

Summary

A novel silanization strategy enables versatile functionalization of metal-organic frameworks (MOFs). This method creates responsive nanovalves for targeted drug delivery, showing significant tumor inhibition with minimal toxicity.

Keywords:

chemotherapy controlled drug release metal−organic framework silane functionalization supramolecular nanovalve

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Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange

Published on: June 23, 2023

Area of Science:

Materials Science
Nanotechnology
Chemical Engineering

Background:

Metal-organic frameworks (MOFs) offer tunable properties for diverse applications.
Functionalization of MOFs is crucial for enhancing their performance and expanding their utility.
Existing MOF modification methods often lack universality and efficiency.

Purpose of the Study:

To develop a universal strategy for silane functionalization of MOFs.
To construct supramolecular nanovalves on MOF surfaces for controlled drug delivery.
To evaluate the therapeutic efficacy and safety of the developed nanovalves.

Main Methods:

Hydrolysis of silanes followed by condensation reactions with MOF hydroxyl groups to form metal-O-Si bonds.
Surface silanization of nanoscale MOFs (NMOFs) with benzimidazole stalks.
Assembly of cyclodextrin polymer (CDP) onto silanized NMOFs to create multivalent nanovalves.

Main Results:

A universal silanization method was established, enabling covalent coupling of silanes to MOFs via metal-O-Si bonds.
CDP-valved NMOFs demonstrated stimuli-responsive controlled release of drugs at low pH and in the presence of α-amylase.
In vitro and in vivo studies confirmed significant tumor growth inhibition and negligible toxicity to normal tissues.

Conclusions:

The developed silanization strategy is a versatile approach for MOF functionalization.
CDP-valved NMOFs show great promise as intelligent drug delivery systems for cancer therapy.
This work opens new avenues for MOF applications in drug delivery, catalysis, and materials science.