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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Jul 28, 2025

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

Synaptic dysfunction in Down syndrome: an emerging role for circulating β2-microglobulin

¹Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA. q0chen@ucsd.edu.

Signal Transduction and Targeted Therapy

|May 29, 2023

Summary

No abstract available in PubMed .

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