Related Experiment Video

Updated: Jul 28, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

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P38 kinase in gastrointestinal cancers

Thuy Phan1, Xu Hannah Zhang2, Steven Rosen2

  • 1Department of Surgery, City of Hope Medical Center, Duarte, CA, USA.

Cancer Gene Therapy
|May 29, 2023
PubMed

Insights

Targeting p38γ, a specific p38 Mitogen Activated Protein Kinase (MAPK), shows promise for treating gastrointestinal cancers. This pathway is linked to cancer development and metastasis, offering a novel therapeutic avenue.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Gastrointestinal cancers cause significant global morbidity and mortality.
  • Current therapies are insufficient to prevent distant metastases.
  • Mitogen-activated protein kinase (MAPK) pathways are critical in cellular processes and cancer development.

Purpose of the Study:

  • To review the role of p38 Mitogen Activated Protein Kinases (p38 MAPKs), focusing on p38γ, in gastrointestinal cancers.
  • To explore targeting p38γ as a potential therapeutic strategy for these cancers.

Main Methods:

  • Literature review of p38 MAPK signaling in gastrointestinal cancers.
  • Analysis of the association between p38γ dysregulation and cancer progression.
  • Discussion of therapeutic implications of targeting p38γ.

Main Results:

  • p38 MAPKs, including p38γ, are implicated in cancer development, metastasis, and the tumor microenvironment.
  • Dysregulation of p38γ pathways is observed in gastrointestinal cancers.
  • p38γ is identified as a key player in cancer progression.

Conclusions:

  • p38γ signaling is a relevant target for novel gastrointestinal cancer therapies.
  • Further research into targeting p38γ could lead to improved treatment outcomes.

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