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miRNAs as biomarkers of musculoskeletal pain in long-distance runners: the MiMuS study protocol

Maria Rosaria Tumolo1,2, Tiziana Grassi1, Carlo Giacomo Leo2,3

  • 1University of Salento, Department of Biological & Environmental Sciences & Technology, 73100 Lecce, Italy.

Epigenomics
|May 30, 2023
PubMed

Insights

MicroRNAs (miRNAs) are linked to musculoskeletal pain in runners. This study explores how specific miRNAs in blood and saliva correlate with pain and treatment response.

Area of Science:

  • Molecular Biology
  • Sports Medicine
  • Biochemistry

Background:

  • Musculoskeletal pain imposes a significant burden on individuals and society.
  • In runners, pain can stem from inflammation or tissue damage, impairing performance.
  • MicroRNAs (miRNAs) are implicated in the development and progression of pain.

Purpose of the Study:

  • To investigate the association between circulating and salivary miRNAs and musculoskeletal pain in runners.
  • To determine if dysregulated miRNAs can differentiate between responders and nonresponders to kinesiological intervention.
  • To explore correlations between miRNAs, inflammatory markers, stress parameters, and individual characteristics.

Main Methods:

  • Analysis of circulating and salivary miRNAs in runners with and without musculoskeletal pain.
  • Evaluation of miRNA association with pain, inflammatory molecules, and stress parameters.
  • In silico analysis to elucidate miRNA functions.

Main Results:

  • Circulating and salivary miRNAs are associated with musculoskeletal pain in runners.
  • Specific miRNA profiles may distinguish between treatment responders and nonresponders.
  • Correlations were observed between miRNAs and inflammatory markers and stress parameters.

Conclusions:

  • miRNAs play a role in musculoskeletal pain pathophysiology in runners.
  • Salivary and circulating miRNAs show potential as biomarkers for pain and treatment response.
  • Further research can leverage these findings for targeted interventions and pain management strategies.
Keywords:
biomarkerinflammationmicroRNAmusculoskeletal painrunners

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