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Electroconvulsive Therapy

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...

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Related Experiment Video

Updated: Jul 28, 2025

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

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Pediatric multiple sclerosis: The 2022 ECTRIMS lecture.

Brenda Banwell¹

¹Brenda BanwellChildren's Hospital of Philadelphia, Grace E. Loeb Chair in Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|May 30, 2023

Summary

This summary is machine-generated.

Prompt recognition and treatment of pediatric-onset multiple sclerosis (POMS) are crucial. Research suggests MS is a single disease across ages, offering unique insights from studying young patients.

Keywords:

ECTRIMS Pediatric multiple sclerosis

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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Area of Science:

Neurology
Immunology
Pediatrics

Background:

Multiple sclerosis (MS) diagnosis in children and youth (pediatric-onset MS or POMS) is increasingly recognized.
The inclusion of pediatric patients in diagnostic criteria has advanced POMS identification.
Research indicates MS is a single disease entity across all age groups.

Purpose of the Study:

To highlight the significance of early POMS recognition and treatment.
To discuss the unique insights gained from studying POMS pathobiology.
To outline the evolving landscape of pediatric MS clinical trials and research.

Main Methods:

Review of current research on POMS epidemiology, genetics, and immunology.
Discussion of emerging pediatric clinical trial designs and regulatory considerations.
Emphasis on international collaborative efforts and POMS research priorities.

Main Results:

MS pathobiology may be better understood through studying younger patients.
Pediatric trials for MS therapies are developing, requiring specific designs and safety focus.
International collaboration is essential due to the rarity of POMS.

Conclusions:

Early diagnosis and treatment are vital for POMS.
Further research and international collaboration are needed to advance POMS care and treatment options.
Long-term safety and efficacy data are critical for pediatric MS therapies.