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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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SARS-CoV-2 induced HDL dysfunction may affect the host's response to and recovery from COVID-19

Hayder M Al-Kuraishy1, Nawar R Hussien2, Marwa S Al-Niemi2

  • 1Department of Pharmacology, Toxicology, Medicine College of Medicine Al-Mustansiriyah University, Baghdad, Iraq.

Immunity, Inflammation and Disease
|May 30, 2023
PubMed

Insights

COVID-19 significantly impacts lipid profiles, particularly high-density lipoprotein (HDL) and low-density lipoprotein (LDL). Reduced HDL levels correlate with severe COVID-19 outcomes, suggesting HDL

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Virology

Background:

  • COVID-19 is associated with cardio-metabolic disorders, including dyslipidemia.
  • SARS-CoV-2 infection causes significant alterations in lipid profiles.
  • Lipid profile changes may serve as biomarkers for COVID-19 diagnosis and management.

Purpose of the Study:

  • To review the impact of COVID-19 on high-risk patients.
  • To explore the relationship between dysfunctional high-density lipoprotein (HDL) and COVID-19 severity.
  • To understand how SARS-CoV-2 infection affects lipid metabolism.

Main Methods:

  • Literature review methodology.
  • Narrative and comprehensive review of existing studies.
  • Analysis of information on COVID-19's effects on high-risk groups.

Main Results:

  • Reduced HDL levels in COVID-19 patients correlate with disease severity and poor outcomes.
  • SARS-CoV-2 binds to HDL, potentially facilitating viral entry.
  • COVID-19 infection can induce dysfunctional HDL through inflammation and oxidative stress, exacerbating disease severity.

Conclusions:

  • COVID-19 is linked to cardio-metabolic disorders like dyslipidemia and dysregulated HDL/LDL.
  • Dysfunctional HDL plays a causal role in COVID-19.
  • Understanding the HDL-COVID-19 relationship is crucial for patient management.
Abstract

Keywords:
Covid-19SARS-CoV-2 infectionangiotensin-converting enzyme 2 (ACE2)cardio-metabolic disordersdyslipidemiahigh-density lipoprotein (HDL)low-density lipoprotein (LDL)

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