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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Axillary Cutaneous Hemosiderosis in a Patient With Hyperhidrosis, After Intravenous Iron Infusion
Angel Fernandez-Flores1,2,3, Miriam Fernandez-Parrado4, Jacques Alzoghby-Abi Chaker5
1Department of Histopathology, University Hospital El Bierzo, Ponferrada, Spain.
The American Journal of Dermatopathology
|May 30, 2023
Summary
Cutaneous siderosis, an iron deposit in the skin, can cause cosmetic concerns. A rare case shows extensive skin hyperpigmentation after intravenous iron infusion in a patient with hyperhidrosis.
Area of Science:
- Dermatology
- Hematology
- Toxicology
Background:
- Hemosiderosis involves iron deposition in tissues without organic damage.
- Cutaneous siderosis can lead to aesthetically displeasing skin discoloration.
- Common causes include venous insufficiency and transfusion-related iron extravasation.
Observation:
- A 31-year-old woman with hyperhidrosis experienced postpartum hemorrhage.
- She received an intravenous iron infusion for anemia.
- Extensive hyperpigmentation developed in both axillae shortly after the iron infusion.
Findings:
- This case highlights a rare instance of diffuse cutaneous siderosis.
- Intravenous iron administration potentially triggered widespread skin hyperpigmentation.
- The patient's hyperhidrosis may have influenced iron deposition patterns.
Implications:
- This presentation expands the understanding of iatrogenic cutaneous siderosis.
- It suggests a need for vigilance regarding skin changes post-intravenous iron therapy.
- Further research may elucidate the mechanisms of iron deposition in hyperhidrotic skin.
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