Related Experiment Video
Updated: Jul 28, 2025
07:10
Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
Published on: September 14, 2014
14.4K
Polyfunctionality of broadly neutralizing HIV-1 antibodies
Lou-Léna Vrignaud1,2, Olivier Schwartz1,2, Timothée Bruel1,2,3
1Virus & Immunity Unit, CNRS UMR3569, Université Paris Cité, Institut Pasteur.
Current Opinion in HIV and AIDS
|May 30, 2023
Summary
Broadly neutralizing HIV-1 antibodies (bNAbs) offer new hope for an HIV cure by inhibiting viral fusion and activating immune cells. Their nonneutralizing functions are crucial for viral clearance and improving therapeutic strategies.
Area of Science:
- Immunology
- Virology
- Vaccinology
Background:
- Broadly neutralizing HIV-1 antibodies (bNAbs) are key to vaccine design and potential HIV-1 cure.
- These antibodies target the HIV-1 Envelope, inhibiting viral fusion with high potency and breadth.
- bNAbs possess nonneutralizing activities that activate immune cells and impede viral spread.
Conclusions:
- Nonneutralizing bNAb activities promote viral clearance and enhance immune responses.
- Understanding and manipulating these functions can improve bNAb-based therapies for HIV-1.
- bNAb polyfunctionality is critical for reservoir targeting and prevention in suboptimal neutralization scenarios.
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