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Related Experiment Videos

Trazodone overdosage: experience over 5 years.

C J Ali, J A Henry

    Neuropsychobiology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Trazodone self-poisoning cases were reviewed. The drug appears to have low toxicity compared to other antidepressants like tricyclic antidepressants and monoamine oxidase inhibitors.

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    Area of Science:

    • Clinical Toxicology
    • Pharmacovigilance

    Background:

    • The UK National Poisons Information Service London Centre receives enquiries regarding drug overdoses.
    • Trazodone is an antidepressant medication with a distinct pharmacological profile.

    Purpose of the Study:

    • To assess the toxicity profile of trazodone in cases of self-poisoning.
    • To compare trazodone's toxicity with other classes of antidepressants.

    Main Methods:

    • Retrospective review of 107 enquiries concerning trazodone self-poisoning.
    • Analysis of clinical data, symptoms, and outcomes from 46 cases with detailed medical information.

    Main Results:

    • 107 trazodone self-poisoning incidents were reported.
    • Detailed data from 46 cases indicated a low toxicity profile for trazodone.

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  • Compared to tricyclic antidepressants and monoamine oxidase inhibitors, trazodone demonstrated lower toxicity.

    • Conclusions:

    • Trazodone appears to be a relatively safe medication in overdose scenarios.
    • The findings suggest a favorable safety margin for trazodone compared to older antidepressant classes.