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Perspective: Daniela Novick, cytokines and their receptors
Pietro Ghezzi1, Giamila Fantuzzi2, Charles A Dinarello3
1Department of Biomolecular Sciences, Università di Urbino, Urbino, Italy.
Frontiers in Immunology
|May 30, 2023
Summary
Dr. Daniela Novick identified cytokine-binding proteins and soluble receptors, advancing the development of targeted therapies like monoclonal antibodies against interferons and cytokines.
Area of Science:
- Immunology
- Molecular Biology
- Biochemistry
Background:
- Cytokines are crucial signaling molecules in immunity and inflammation.
- Understanding cytokine-binding proteins is essential for developing targeted immunotherapies.
Purpose of the Study:
- To highlight the significant contributions of Dr. Daniela Novick to cytokine biology.
- To review her foundational work in identifying cytokine-binding proteins and receptors.
Main Methods:
- Affinity chromatography was employed to characterize cytokine-binding proteins.
- Biochemical techniques were used to identify soluble receptor forms and binding proteins.
Main Results:
- Identified soluble receptor forms for multiple cytokines.
- Characterized binding proteins for tumor necrosis factor, interleukin-6, interleukin-18, and interleukin-32.
- Dr. Novick's research was pivotal in developing monoclonal antibodies against interferons and cytokines.
Conclusions:
- Dr. Novick's work has substantially advanced the understanding of cytokine interactions.
- Her findings have direct implications for the development of novel immunomodulatory drugs and therapies.