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Central precocious puberty in Prader-Willi syndrome: a narrative review
Delia-Maria Nicoară1, Alexandra-Cristina Scutca1,2, Niculina Mang1
1Department of Pediatrics, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
Abstract:
Prader-Willi syndrome (PWS, OMIM176270) is a rare genetic disorder with recognizable dysmorphic features and multisystemic consequences such as endocrine, neurocognitive and metabolic ones. Although most patients with Prader-Willi syndrome exhibit hypogonadotropic hypogonadism, there is variability regarding sexual maturation, with precocious puberty occurring in rare cases. Our aim is to elaborate a thorough review of Prader-Willi patients with central precocious puberty, in order to raise awareness of such cases and to enhance our knowledge regarding the diagnosis and prompt treatment of this particular PWS patients.
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