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Evaluation of the Correlation between Coronary Artery Disease and Nonalcoholic Fatty Liver Disease: Is There Any

Zahra Momayez Sanat1, Seyyed Mojtaba Ghorashi2,3, Ava Ajir1

  • 1Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

The Journal of Tehran Heart Center
|May 30, 2023
PubMed

Insights

Nonalcoholic fatty liver disease (NAFLD) is prevalent in patients with coronary artery disease (CAD). NAFLD is an independent risk factor for CAD, suggesting routine screening for CAD in NAFLD patients.

Area of Science:

  • Cardiology
  • Hepatology
  • Public Health

Background:

  • Coronary artery disease (CAD) and nonalcoholic fatty liver disease (NAFLD) are globally prevalent conditions.
  • Investigated the prevalence of NAFLD in patients diagnosed with CAD and explored the association between these two diseases.

Purpose of the Study:

  • To determine the prevalence of NAFLD in patients with CAD.
  • To assess the relationship between NAFLD and CAD.

Main Methods:

  • A case-control study conducted from January 2017 to January 2018 at Ziaeian Hospital, Tehran, Iran.
  • Included 180 participants (35-75 years) undergoing myocardial perfusion imaging, divided into CAD+ and CAD- groups based on >50% coronary artery stenosis.
  • NAFLD was evaluated using abdominal sonography and laboratory tests; patients with other liver conditions were excluded.

Main Results:

  • The study included 122 women (67.8%) and 58 men (32.2%) with a mean age of 49.31±5.42 years.
  • NAFLD was detected in 115 patients, with a prevalence of 78.9% in the CAD+ group.
  • NAFLD was identified as an independent risk factor for CAD, with an odds ratio of 3.9.

Conclusions:

  • High prevalence of NAFLD observed in the coronary artery disease patient group.
  • Given the rising incidence of fatty liver disease and obesity, CAD screening is recommended for all NAFLD patients.
Abstract

Keywords:
Adverse effectsCoronary artery diseaseMyocardial perfusion imagingNonalcoholic fatty liver disease

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