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Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet
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Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet

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Role of flavonoids in controlling obesity: molecular targets and mechanisms

Anns Mahboob1, Samson Mathews Samuel2, Arif Mohamed3

  • 1Department of Pre-medical Education, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar.

Frontiers in Nutrition
|May 30, 2023
PubMed

Insights

Obesity, a complex inflammatory disease, contributes to numerous health issues and premature death. This study explores how flavonoids may offer a long-term solution for obesity treatment by targeting inflammation and gut health.

Area of Science:

  • Metabolic and Inflammatory Diseases
  • Nutritional Biochemistry
  • Pharmacology

Background:

  • Obesity is a significant global health challenge, increasing the risk of diabetes, cardiovascular diseases, cancers, and other non-communicable illnesses.
  • Current obesity treatments, focusing on calorie restriction and expenditure, often lack long-term efficacy.
  • Obesity is characterized as a multifactorial disease driven by inflammation and oxidative stress.

Purpose of the Study:

  • To elucidate the pathophysiology of obesity as an inflammatory and oxidative stress-dependent condition.
  • To evaluate current anti-obesity strategies and assess the potential of flavonoid-based interventions.
  • To explore the long-term efficacy of naturally occurring flavonoids in preventing and treating obesity.

Main Methods:

  • Review of existing literature on obesity pathophysiology and treatment strategies.
  • Analysis of the impact of flavonoids on key metabolic processes: digestion, absorption, and macronutrient metabolism.
  • Evaluation of flavonoid effects on inflammation, oxidative stress, and gut microbiota composition.

Main Results:

  • Flavonoids demonstrate potential therapeutic effects by modulating inflammation and oxidative stress.
  • Interventions with flavonoids may positively influence digestion, absorption, and macronutrient metabolism.
  • Naturally occurring flavonoids show promise in altering gut microbiota profiles relevant to obesity management.

Conclusions:

  • Flavonoid-based therapies offer a promising avenue for the long-term prevention and treatment of obesity.
  • Targeting inflammation, oxidative stress, and gut microbiota with flavonoids presents a novel therapeutic approach.
  • Further research into specific flavonoids and their mechanisms is warranted for clinical application in obesity management.
Keywords:
anti-obesity therapyflavonoidsmetabolic syndromenatural compoundsobesity

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